Transgenic animal as a model for fibrotic diseases

Details Transgenic animal as a model for fibrotic diseases Transgenic animal as a model for fibrotic diseases

A - Human Necessities

01

K

A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2598859

A transgenic non-human animal with broad or cell type-specific ectopic expression offra-2 that manifests itself in a fibrotic disease, methods for obtaining such animal and their use. Fra-2 transgenic animals, in particular mice, are useful as model Systems for human fibrotic disease, e.g. lung scleroderma and pulmonary fibrosis. Cells obtained from the animal are useful for the analysis of fibrotic disease and for testing Compounds useful in the therapy of fibrotic disease.

L'invention concerne un animal transgénique non humain présentant une expression ectopique de fra-2 spécifique d'un type de cellule ou étendue qui se manifeste dans une maladie de type fibreux, des méthodes permettant d'obtenir l'animal et son utilisation. Les animaux transgéniques fra-2, en particulier, la souris, sont utilisés comme modèle pour les maladies humaines de type fibreux, par exemple, la sclérose pulmonaire et la fibrose pulmonaire. Les cellules obtenues à partir de l'animal sont utilisées pour analyser une maladie de type fibreux et pour soumettre des composés utilisés dans la thérapie d'une maladie de type fibreux à un essai.

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