Methods of identifying anti-inflammatory compounds

Details Methods of identifying anti-inflammatory compounds Methods of identifying anti-inflammatory compounds

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 37/06 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2722173

A mammalian C-type lectin receptor type is identified which is shown to bind IgG antibodies or Fc fragments, thus inducing IVIG-related reversal of inflammation associated with various immune disorders. The identification of a DC- SIGN receptor type which interacts with IgG to promote a biological response reducing inflammation associated with immune disorders provides for methods of screening and selecting compounds which may be useful in treating various immune disorders by acting to modulate a DC-SIGN1+1 cell to signal a second effector macrophage, causing an increase in expression of the Fc.gamma.RIIB receptor and in turn inhibiting a cellular-mediated inflammatory response.

On a identifié un type de récepteur mammalien de lectine du type C dont il a été démontré qu'il se lie à des anticorps IgG ou des fragments Fc, induisant ainsi une inversion liée aux IVIG de l'inflammation associée à divers troubles immuns. L'identification d'un type de récepteur DC-SIGN qui interagit avec les IgG pour promouvoir une réponse biologique réduisant l'inflammation associée à des troubles immuns permet d'utiliser des procédés de criblage et de sélection de composés qui peuvent être utiles pour traiter divers troubles immuns en agissant sur la modulation d'une cellule DC-SIGN1+1 pour signaler un second macrophage effecteur, qui induit un accroissement de l'expression du récepteur Fc?RIIB et inhibe, à son tour, une réponse inflammatoire à médiation cellulaire.

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