Triazolopyridinone derivatives for use as stearoyl coa...

Details Triazolopyridinone derivatives for use as stearoyl coa... Triazolopyridinone derivatives for use as stearoyl coa...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/00 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2719288

The present invention discloses triazolopyridinone derivatives for use as inhibitors of stearoyl-CoA desaturase hav-ing the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.

La présente invention concerne des dérivés triazolopyridinone destinés à être utilisé comme inhibiteurs de la stéaroyl-CoA désaturase comportant la structure de formule I. Les composés sont utiles dans le traitement et/ou la prévention de diverses maladies humaines, véhiculées par des enzymes de stéaroyl-CoA désaturase (SCD), particulièrement des maladies liées à des niveaux de lipide anormaux, à une maladie cardiovasculaire, au diabète, à lobésité, au syndrome métabolique et similaires.

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