Substituted benzodioxepines

Details Substituted benzodioxepines Substituted benzodioxepines

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/404 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2511021

Disclosed are benzodioxepins of formula (I) and the physiologically acceptable salts and solvates thereof, R1, R2, R3, R4, A, B, a, and b having the meanings indicated in claim 1. Said benzodioxepins are ligands of the 5HT1A receptors and/or 5HT4 receptors while greatly inhibiting serotonin reuptake. The inventive benzodioxepins can be used for the treatment and prophylaxis of different diseases.

L'invention concerne des benzodioxépines de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, A, B, a et b ont les significations indiquées dans la revendication n·1, ainsi que leurs sels et solvates physiologiquement tolérables, ces composés étant des ligands des récepteurs 5HT1A et/ou des récepteurs 5HT4 possédant également une forte action inhibitrice de la réabsorption de la sérotonine. Lesdits composés peuvent être utilisés en traitement ou prévention de différentes maladies.

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