Ifnar2 mutants, their production and use

Details Ifnar2 mutants, their production and use Ifnar2 mutants, their production and use

C - Chemistry, Metallurgy

12

N

C12N 15/22 (2006.01) A61K 38/21 (2006.01) C07K 14/715 (2006.01) C12N 15/20 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2470245

The present invention relates to mutant polypeptides of the beta chain of the type I IFN receptor (IFNAR2 mutant) with enhanced affinity for interferon-beta as compared to the wild type protein for prolonging the effect of IFN-beta in vivo.

la présente invention concerne des polypeptides mutants de la chaîne bêta du récepteur IFN de type I (mutant IFNAR2t) présentant par rapport à la protéine de type sauvage une affinité accrue pour l'interféron .beta. et permettant de prolonger l'effet de IFN-.beta. in vivo.

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