Sustained release compositions

Details Sustained release compositions Sustained release compositions

A - Human Necessities

61

K

A61K 47/34 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 31/00 (2006.01) A61K 31/4436 (2006.01) A61K 31/519 (2006.01) A61K 38/09 (2006.01) A61K 45/00 (2006.01) A61P 5/24 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2407472

Compositions containing a nonpeptidyl physiologically active substance and a biodegradable polymer having two or more terminal carboxyl groups or its salt which have the following characteristics: (1) the content of the nonpeptidyl physiologically active substance can be elevated and the release thereof can be regulated or accelerated to thereby ensure the achievement of the pharmacological effect; (2) in case where the nonpeptidyl physiologically active substance has subcutaneous irritation, it is expected that the irritation can be overcome by the terminal groups having a high acidity; and (3) having a high glass transition point and thus being highly stable.

L'invention porte sur des compositions contenant une substance physiologiquement active non peptidyle et un polymère biodégradable à deux (ou plus) groupes carboxyle terminaux ou ses sels, et présentant les caractéristiques suivantes: (1) la teneur en substance physiologiquement active non peptidyle peut être accrue, et sa libération peut être accélérée ou ralentie pour atteindre les effets pharmacologiques souhaités; (2) au cas où la substance physiologiquement active non peptidyle produise une irritation, cette dernière doit pouvoir être traitée par les groupes terminaux fortement acides; et (3) la substance, qui présente un point de transition vitreuse élevé, est donc extrêmement stable.

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