Nucleic acids, proteins, and antibodies

Details Nucleic acids, proteins, and antibodies Nucleic acids, proteins, and antibodies

C - Chemistry, Metallurgy

12

N

C12N 1/13 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2394841

The present invention relates to novel connective tissue related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "connective tissue antigens", and the use of such connective tissue antigens for detecting disorders of connective tissue(s), particularly the presence of cancer and cancer metastases. More specifically, isolated connective tissue associated nucleic acid molecules are provided encoding novel connective tissue associated polypeptides. Novel connective tissue polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human connective tissue associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to connective tissue(s), including cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonsits of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

La présente invention concerne de nouveaux polynucléotides liés au(x) tissu(s) conjonctif(s), et les polypeptides codés par ces polynucléotides connus ici sous la dénomination collective de "antigènes de tissu(s) conjonctif(s)", et l'utilisation d'antigènes de tissu(s) conjonctif(s)de ce type pour détecter des troubles liés aux testicules, en particulier la présence du cancer et de métastases cancéreuses. Plus spécifiquement, l'invention concerne des molécules d'acide nucléique isolées associées au(x) tissu(s) conjonctif(s), codant pour de nouveaux polypeptides associés au(x) tissu(s) conjonctif(s). Cette invention concerne également des polypeptides et anticorps testiculaires qui se lient à ces polypeptides ; des vecteurs, des cellules hôtes, des procédés de recombinaison et de synthèse permettant de produire des polynucléotides et/ou polypeptides humains associés au(x) tissu(s) conjonctif(s); des procédés diagnostiques et thérapeutiques utiles pour le diagnostic, le traitement, la prévention et/ou la prévision de troubles liés au(x) tissu(s) conjonctif(s), y compris le cancer, et des procédés de traitement de troubles de ce type ; des procédés de criblage permettant d'identifier des agonistes et des antagonistes de polynucléotides et polypeptides de l'invention ; des procédés et/ou des compositions permettant d'inhiber la production et la fonctionnalité de polypeptides de la présente invention.

Affiliated with

Also associated with

Rating

Nucleic acids, proteins, and antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids, proteins, and antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids, proteins, and antibodies will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1535200