Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2533889

The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des composés à base de dihydropyrrole convenant au traitement d'affections proliférantes cellulaires, au traitement de troubles associés à l'activité de la kinésine KSP, et à l'inhibition de la kinésine KSP. L'invention concerne également, d'une part des compositions comprenant ces composés, et d'autre part des procédés permettant de les utiliser pour le traitement de cancers chez des mammifères.

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