C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/00 (2006.01) G01N 33/566 (2006.01) G06F 17/00 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2361373
The present invention provides methods to provide a set of probes that hybridize or bind relatively well to their intended targets but that do not substantially bind or hybridize to unintended targets. The quality of hybridizing or binding relatively well to intended targets but not to unintended targets may be quantified using delta Tm according to the methods of the present invention. The present invention also provides sets of probes produced according to the subject methods and programmed computer systems functional to perform the subjects methods.
L'invention concerne des techniques permettant de fournir un ensemble de sondes qui s'hybrident ou se lient relativement bien aux cibles souhaitées, mais qui s'hybrident ou se lient sensiblement aux cibles non souhaitées. La qualité de l'hybridation ou de la liaison peut être quantifiée à l'aide de delta Tm en fonction des techniques de l'invention. Cette invention fournit également des ensembles de sondes produites en fonction desdites techniques, et des systèmes informatiques programmés fonctionnellement de façon à utiliser les techniques décrites.
Anderson Brooke P.
Montgomery Donald D.
Combimatrix Corporation
Smart & Biggar
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