C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/775 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2314397
A peptide derived from apolipoprotein E termed apoEp1.B which includes amino acids 239-252 of the apolipoprotein E is described. The apoEp1.B peptide is a potent immune modulator that acts on a variety of immune cells. Interestingly, apoEp1.B is a dual modulator, capable of both inducing and suppressing an immune response. In particular, apoEp1.B has been shown to induce differentiation of stem cells into dendritic cells, to induce tumor cell differentiation and activation, to inhibit inflammation and to inhibit autoimmune disease.
L'invention concerne un peptide issu de l'apolipoprotéine E, appelé apoEp1.B et comprenant les acides aminés 239-252 de l'apolipoprotéine E. Le peptide apoEp1.B est un puissant modulateur immunitaire agissant sur une série de cellules immunitaires. Il est intéressant de noter que l'on est en présence d'un modulateur double, capable à la fois d'induire et de supprimer une réponse immunitaire. En particulier, il apparaît que ce peptide induit une différenciation des cellules souches dans les cellules dendritiques, une différenciation et une activation des cellules tumorales, et une inhibition de l'inflammation et des maladies auto-immunes.
Rider Beverley
Singh Bhagirath
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Western Ontario
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