Recombinant measles viruses expressing epitopes of antigens...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 47/48 (2006.01) C07K 14/12 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2493834

The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus. It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.

La présente invention concerne un virus de la rougeole recombiné qui exprime une séquence d'acides aminés hétérologue dérivée d'un antigène d'un ARN virus déterminé, ledit virus de la rougeole recombiné étant capable de provoquer une réponse immunitaire humorale et/ou cellulaire contre le virus de la rougeole et/ou contre ledit ARN virus. L'invention se rapporte également à l'utilisation du virus de la rougeole recombiné précité dans la préparation d'une composition immunogène.

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