Use of dopamine d2/d3 receptor agonists to treat fibromyalgia

A - Human Necessities – 61 – K

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A61K 31/428 (2006.01) A61K 31/404 (2006.01)

Patent

CA 2414774

The present invention is directed to methods for the treatment of human patients afflicted with fibromyalglia using a non-ergot dopamine receptor D2/D3 agonist. In particular, patients are treated with a therapeutically effective amount of tetrahydro-benzthiazole or 3(H)-indolone compounds that are dopamine agonists. More specifically, the compounds 2-amino-6-n- propylamino-4,5,6,7-tetrahydrobenzo-thiazole or 4-[2-(dipropylamino)-ethyl]- 1,3-dihydro-2H-indol-2-one are administered to fibromyalgia patients to reduce the musculoskeletal pain symptoms associated with fibromyalgia.

L'invention concerne des méthodes de traitement de patients humains souffrant de fibromyalgie au moyen d'un agoniste du récepteur D2/D3 de la dopamine non dérivé de l'ergot. D'une manière spécifique, lesdits patients sont traités au moyen d'une quantité efficace du point de vue thérapeutique de composés tétrahydro-benzothiazole ou de composés 3(H)-indolone qui sont des agonistes de la dopamine. D'une manière plus spécifique, les composés 2-amino-6-n-propylamino-4,5,6,7-tétrahydrobenzo-thiazole ou 4-[2-(dipropylamino)-éthyl]-1,3-dihydro-2H-indol-2-one sont administrés à des patients souffrant de fibromyalgie afin de réduire les symptômes de douleur musculo-squelettique associés à la fibromyalgie.

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