C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) C07K 14/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2340308
There is currently little understanding of the genetic basis for virulence or growth control in viruses. The invention provides methods of identifying mutations that control viral virulence and growth as well as the application of the detection of these mutations to diagnostic and therapeutic purposes. This patent identifies a process of selecting viral variants that accumulate biologically relevant mutations. The process involves the serial culturing of large populations of virus under conditions of restricted replication in this instance in the lung of mice but can include other types of tissues, that selects viruses with mutations that both increase replication and virulence. These mutations also involve regions of proteins that are in involved in controlling aspects of specific viral protein and RNA interactions. These regions define targets for antiviral drug intervention.
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