C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2183157
The present invention relates to compounds which have immunosuppressive effects in mammals. In particular, the invention provides a protein which suppresses allograft rejection in a mammalian recipient. The protein is found in serum of a post liver transplantation subject and has a molecular weight selected from a molecular weight of about 10 kD, about 40 kD or about 87 kD, or is a homologue of a 10 kD, 40 kD or 87 kD protein found in serum of a post liver transplantation rat. The invention also provides a method of identifying immunosupressive proteins, a process for preparing immunosupressive proteins, compositions comprising immunosuppressive proteins and a method of suppressing allograft rejection in a mammalian recipient of a graft.
Composés ayant une action d'immunodépression chez les mammifères. Il s'agit notamment d'une protéine apte à supprimer le rejet de greffe allogénique chez un receveur mammifère. Cette protéine que l'on trouve dans le sérum d'un sujet ayant subi une greffe du foie, a un poids moléculaire choisi parmi des poids moléculaires de 10 kD environ, de 40 kD environ, ou de 87 kD environ, ou est un homologue d'une protéine de 10 kD, de 40 kD ou de 87 kD que l'on trouve dans le sérum d'un rat ayant subi une greffe du foie. On a également prévu un procédé d'identification des protéines d'immunodépression, leur procédé de préparation, des compositions comportant ces protéines d'immunodépression, et un procédé de suppression du rejet de greffe allogénique chez le receveur mammifère d'une greffe.
Kamada Naoshi
Ridout & Maybee Llp
LandOfFree
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