Powders for inhalation

Details Powders for inhalation Powders for inhalation

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/155 (2006.01) A61K 47/42 (2006.01) B01D 1/18 (2006.01) B01J 2/04 (2006.01)

Patent

CA 2654264

The invention relates to powder containing protein, the phenylalanine part amounting to at least 30% (w/w), or at least 40% (w/w). It has been shown that powder containing phenylalanine is highly suitable, in terms of aerodynamic behaviour and protein stabilisation, especially after spray drying, for producing powders or protein compositions with improved aerodynamic properties. The main constituent is phenylalanine and the optional other constituent is an auxiliary agent, preferably a sugar or a polyol, which is highly water-soluble compared to phenylalanine.

L'invention concerne une poudre protéinée, la fraction de phénylalanine s'élevant à au moins 30% (w/w), voire à au moins 40% (w/w). Il a été démontré qu'en termes de comportement aérodynamique et de stabilisation des protéines notamment après séchage par pulvérisation, la poudre contenant de la phénylalanine convient parfaitement à la production de poudres ou compositions de protéines aux propriétés aérodynamiques améliorées. Les principaux constituants, la phénylalanine et les éventuels autres constituants, sont un auxiliaire de bonne hydrosolubilité par rapport à la phénylalanine, de préférence, un sucre ou un polyol.

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