A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/21 (2006.01) A61J 1/00 (2006.01)
Patent
CA 2523477
A container comprising a closure means coated by an inert fluorinated material and containing a liquid pharmaceutical composition. In particular, the container comprises a closure means coated by TEFLON and contains a HSA-free Interferon-.beta. formulation having the following composition: 30 to 100 ~g/ml of interferon-.beta., an isotonicity agent, 0.1 to 2 mg/ml of Poloxamer 188, at least 0.12 mg/ml of L-Methionine and a buffer solution capable of maintaining the pH of the liquid formulation at a value between 3.0 and 4Ø
La présente invention a trait à un emballage comportant un moyen de fermeture revêtu d'un matériau fluoré contenant une composition pharmaceutique à l'état liquide, notamment l'emballage comporte un moyen de fermeture revêtu de Téflon et contient une formulation d'interféron beta exempte de l'albumine sérique humaine constituée de la manière suivante : 30 à 100 mu g/ml d'interféron beta , d'un agent isotonique, 0,1 à 2 mg/ml de Poloxamère 188, au moins 0,12 mg/ml de L-méthionine et une solution tampon capable de maintenir le pH de la formulation liquide à une valeur comprise entre 3,0 et 4,0.
Del Rio Alessandra
Samaritani Fabrizio
Ares Trading S.a.
Kirby Eades Gale Baker
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