C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/444 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2387719
Azaindolizinon derivatives or pharmaceutically acceptable salts thereof represented by the formula I: (see formula I) wherein R1 represents hydrogen atom, halogen atom or C1-C6 alkyl, R2 represents hydrogen atom, C1-C6 alkyl, C1-C6alkoxy, hydroxy, halogen atom, amino, acetylamino, benzylamino, trifluoromethyl or -O- (CH2)n-R5 (R5 represents vinyl, C3--C8 cycloalkyl or phenyl, n being 0 or 1), R3 and R4 respectively represent C1-C6 alkyl or -CH(R7)-R6 (wherein R6 represents vinyl, ethynyl, phenyl (which may be substituted with C1-C6 alkyl, C1-C6 alkoxy, hydroxy, one or two halogen atoms, di C1-C6 alkylamino, cyano, nitro, carboxy or phenyl), phenethyl, pyridyl, thienyl or furyl and R7 represents hydrogen atom or C1-C6 alkyl) or R3 is coupled with R4 to form indan or dihydrophenalene.
L'invention concerne des dérivés d'azaindolizinone de la formule générale (I) ou des sels pharmaceutiquement acceptables desdits dérivés. Dans ladite formule, R¿1? est hydrogène, halogéno, ou alkyle C¿1?-C¿6?; R¿2? est hydrogène, alkyle C¿1?-C¿6? ou analogue; R¿3? et R¿4? sont l'un et l'autre alkyle C¿1?-C¿6? ou CH(R¿7?)-R¿6? (R¿6? étant vinyle, éthynyle, phényle ou analogue; R¿7? étant hydrogène ou alkyle C¿1?-C¿6?), ou bien R¿3? et R¿4? peuvent être associés pour former un noyau indane ou dihydrophénalène.
Fukuda Naoki
Higashi Masaya
Kawashima Seiichiro
Matsuno Toshiyuki
Saitoh Kenichi
Fetherstonhaugh & Co.
Zenyaku Kogyo Kabushiki Kaisha
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