Increased lysine production by gene amplification

Details Increased lysine production by gene amplification Increased lysine production by gene amplification

C - Chemistry, Metallurgy

12

N

C12N 15/60 (2006.01) C07K 14/34 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 9/06 (2006.01) C12N 9/12 (2006.01) C12N 9/88 (2006.01) C12N 15/31 (2006.01) C12N 15/52 (2006.01) C12N 15/53 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01) C12P 13/08 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2654770

The invention provides methods to increase the production of an amino acid from Corynebacterium species by way of the amplication of amino acid biosynthetic pathway genes in a host cell chromosome. In a preferred embodiment, the invention provides methods to increase the production of L-Lysine in Corynebacterium glutamicum by way of the amplification of L-lysine biosynthetic pathway genes in a host cell chromosome. The invention also provides novel processes for the production of an amino acid by way of the amplification of amino acid biosynthetic pathway genes in a host cell chromosome and/or by increasing promoter strength. In a preferred embodiment, the invention provides processes to increase the production of L-lysine in Corynebacterium glutamicum by way of the amplification of L-lysine biosynthetic pathway genes in a host cell chromosome. The invention also provides novel isolated nucleic acid molecules for L-lysine biosynthetic pathway genes of Corynebacterium glutamicum.

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