A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/4188 (2006.01)
Patent
CA 2729914
The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound and (b) a compound which modulates the Ras/Raf/Mek pathway for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.
L'invention concerne une combinaison pharmaceutique qui comporte (a) un composé inhibiteur de phosphoinositide 3-kinase et (b) un composé qui module la voie Ras/Raf/Mek pour le traitement d'une maladie proliférative, en particulier dune maladie à tumeur solide ; une composition pharmaceutique comportant une telle combinaison ; l'utilisation d'une telle combinaison pour la préparation d'un médicament destiné au traitement d'une maladie proliférative ; un conditionnement ou produit commercial comportant une telle combinaison sous forme de préparation combinée, pour une utilisation simultanée, séparée ou séquentielle, et un procédé de traitement d'un animal à sang chaud, en particulier un être humain.
Fritsch Christine
Garcia-Echeverria Carlos
Maira Sauveur-Michel
Nagel Tobi
Stuart Darrin
Fetherstonhaugh & Co.
Novartis Ag
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