Solid retigabine in non-crystalline form

Details Solid retigabine in non-crystalline form Solid retigabine in non-crystalline form

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 31/167 (2006.01)

Patent

CA 2760043

The invention relates to solid retigabine in non-crystalline form together with a surface stabiliser in the form of a stable intermediate. In the intermediate of the invention, retiga-bine is preferably present in amorphous form or in the form of a solid solution. The in-vention further relates to processes for the production of retigabine in a solid, non-crys-talline form and to pharmaceutical formulations containing solid, non- crystalline retiga-bine.

L'invention porte sur la rétigabine solide sous une forme non-cristalline associée à un stabilisant superficiel, sous la forme d'un intermédiaire stable. Dans l'intermédiaire selon l'invention, la rétigabine se présente de préférence sous forme amorphe ou sous forme d'une solution solide. L'invention concerne en outre un procédé de préparation de rétigabine sous une forme solide non cristalline, et des formulations pharmaceutiques contenant de la rétigabine solide non cristalline.

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