Modified leptin with reduced immunogenicity

Details Modified leptin with reduced immunogenicity Modified leptin with reduced immunogenicity

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 9/70 (2006.01) A61K 38/22 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/54 (2006.01) C07K 14/575 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/09 (2006.01) A61K 38/00 (2006.01) A61K 38/11 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2437265

The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human obesity protein (leptin) to result in leptin proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

La présente invention concerne des polypeptides destinés à être administrés spécifiquement à l'homme et en particulier pour un usage thérapeutique. Les polypeptides sont des polypeptides modifiés qui sont tels que la modification produit, pour le polypeptide, une propension réduite à déclencher une réponse immunitaire lorsqu'on les administre à un patient humain. Cette invention concerne plus particulièrement la modification de la protéine de l'obésité chez l'homme (leptine) pour produire des protéines leptines qui sont sensiblement non immunogènes ou moins immunogènes que n'importe quelle protéine homologue non modifiée lorsqu'on les utilise in vivo.

Affiliated with

Also associated with

Rating

Modified leptin with reduced immunogenicity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified leptin with reduced immunogenicity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified leptin with reduced immunogenicity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1539220