Use of tyrosine kinase inhibitors for whitening human skin...

Details Use of tyrosine kinase inhibitors for whitening human skin... Use of tyrosine kinase inhibitors for whitening human skin...

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 45/00 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2461183

The present invention relates to a method for whitening human skin and treating melanocyte dysfunction associated diseases comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

La présente invention concerne un procédé destiné à blanchir la peau et à traiter des troubles associés à un dysfonctionnement des mélanocytes. Le procédé selon l'invention consiste à administrer un inhibiteur de tyrosine kinase à un humain nécessitant un tel traitement, en particulier un inhibiteur de c-kit puissant, sélectif, non-toxique. De préférence, ledit inhibiteur ne peut pas provoquer la mort de cellules dépendant de IL-3 cultivées en présence de IL-3.

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