A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/29 (2006.01) A61P 37/04 (2006.01) C12N 15/51 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) C07K 14/61 (2006.01) C12N 15/18 (2006.01)
Patent
CA 2068863
A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the sequences comprising, in the 5' to 3' direction, a regulatory sequence operable in the tissue cells and a gene positioned downstream of the regulatory sequence and under the transcriptional control thereof; and (b) accelerating the microprojectiles at the cells, with the microprojectiles contacting the cells at a speed sufficient to penetrate the cells and deposit the polynucleic acid sequences therein. Preferably, the target cells reside in situ in the animal subject when they are transformed. Preferred target cells are dermis or hypodermis cells, and preferred genes for insertion into the target cells are genes which code for proteins or peptides which produce a physiological response in the animal subject.
Johnston Stephen A.
Mcelligott Sandra G.
Sanford John C.
Williams R. Sanders
Cornell Research Foundation Inc.
Duke University
E.i. Du Pont de Nemours And Company
Sim & Mcburney
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