Diaminobenzoic acid derivatives

Details Diaminobenzoic acid derivatives Diaminobenzoic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 237/30 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/245 (2006.01) A61K 31/33 (2006.01) C07C 229/62 (2006.01) C07C 229/64 (2006.01) C07C 243/38 (2006.01) C07C 251/48 (2006.01) C07C 255/60 (2006.01) C07D 209/46 (2006.01) C07D 209/48 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 241/42 (2006.01) C07D 307/88 (2006.01)

Patent

CA 2109975

Abstract Diaminobenzoic acid derivatives The invention relates to compounds of the formula I Image (I) in which A1 and A2 are hydrogen, unsubstituted or substituted lower alkyl, lower alkenyl or lower alkynyl, heterocyclyl-lower-alkyl, acyl, lower alkylsulfonyl or arylsulfonyl, or together are unsubstituted or substituted lower alkylene; Ar1 and Ar2 are aryl, heteroaryl or unsubstituted or substituted cycloalkyl, X is O or S, Y is amino, substituted amino, substituted lower alkoxy or unsubstituted or substituted lower alkylthio; or, if X is O and Z is substituted methyl, Y is hydroxyl; and Z is substituted methyl, carboxyl or esterified or amidated carboxyl or thiocarboxyl; or Y and Z together are 1-oxamethylene; to salts thereof, tautomers thereof, processes for their preparation, pharmaceutical compositions, and/or to these compounds for the therapeutic treatment of the human or animal body or for the preparation of pharmaceutical compositions. The compounds inhibit protein kinases.

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