Solid pharmaceutical formulations containing a physical...

Details Solid pharmaceutical formulations containing a physical... Solid pharmaceutical formulations containing a physical...

A - Human Necessities

61

K

A61K 47/40 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2289202

Sulfoalkyl ether-cyclodextrin (SAE-CD) based pharmaceutical formulations are provided by the present invention. These formulations comprise SAE-CD derivatives and a therapeutic agent, a major portion of which is not complexed to the SAE-CD. The present formulations are advantageously easier to prepare than other SAE-CD based formulations in the art yet provide similar or improved effectiveness. The SAE-CD derivative can be used to modify the bioavailability and/or rate of bioabsorption of therapeutic agents.

La présente invention concerne des formulations pharmaceutiques à base de sulfoalkyl éther-cyclodextrine (SAE-CD), lesquelles contiennent des dérivés de SAE-CD et un agent thérapeutique, dont la majeure partie n'est pas liée par complexe à la SAE-CD. Les formulations de la présente invention offrent l'avantage d'une préparation plus facile que les autres formulations à base de SAE-CD de l'état antérieur de la technique tout en possédant une efficacité similaire, voire améliorée. Le dérivé de SAE-CD peut être utilisé pour modifier la biodisponibilité et/ou le taux de bioabsorption des agents thérapeutiques.

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