C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/5517 (2006.01) A61P 15/12 (2006.01) C07D 243/00 (2006.01) C07D 249/00 (2006.01)
Patent
CA 2578370
Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein R represents H, C1-6 alkyl, SO2R1, SO2NR1R2, or COR1; R1 and R2 independently represent C1-6alkyl; and Ring A represents a phenyl ring or a pyridinyl ring; may be useful in the treatment of anxiety, cardiovascular disease (including angina, atherosclerosis, hypertension, heart failure, edema, hypernatremia), dysmenorrhoea (primary and secondary), endometriosis, emesis (including motion sickness), intrauterine growth retardation, inflammation (including rheumatoid arthritis), mittlesmerchz, preclampsia, premature ejaculation, premature (preterm) labor and Raynaud's disease.
L'invention concerne les composés représentés par la formule (I), (I), ou des dérivés pharmaceutiquement acceptables de ceux-ci. R représente H, alkyle C1-6, SO2R1, SO2NR1R2, ou COR1; R1 et R2 représentant chacun séparément alkyle C1-6; et le noyau A représente un noyau phényle ou un noyau pyridinyle. Ces composés peuvent servir au traitement de l'anxiété, des maladies cardio-vasculaires (notamment l'angor, l'athérosclérose, l'hypertension, l'insuffisance cardiaque, les oedèmes, et l'hypernatrémie), des dysménorrhées (primaires et secondaires), de l'endométriose, des vomissements (y compris les maux de voyage), du retard de croissance intra-utérin, des inflammations (y compris la polyarthrite rhumatoïde), du syndrome intermenstruel, de la prééclampsie, de l'éjaculation précoce, de l'accouchement prématuré(avant terme), et de la maladie de Raynaud.
Pfizer Inc.
Sim & Mcburney
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