C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) C12N 1/14 (2006.01) C12N 5/10 (2006.01) C12N 15/52 (2006.01)
Patent
CA 2558635
The present invention provides methods for generating CMP-sialic acid in a non- human host which lacks endogenous CMP-Sialic by providing the host with enzymes involved in CMP-sialic acid synthesis from a bacterial, mammalian or hybrid CMP-sialic acid biosynthetic pathway. Novel fungal hosts expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided.
La présente invention concerne des procédés qui permettent de produire du CMP-acide sialique chez un hôte non humain déficitaire en CMP-acide sialique endogène, en introduisant dans l'hôte des enzymes actives dans la synthèse de CMP-acide sialique provenant d'une voie de biosynthèse bactérienne, mammalienne ou hybride CMP-acide sialique. L'invention concerne en outre de nouveaux hôtes fongiques exprimant une voie de biosynthèse CMP-acide sialique destinée à la production de glycoprotéines sialylées.
Glycofi Inc.
Smart & Biggar
LandOfFree
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