Variants of the major allergen phl p 1 from timothy grass

Details Variants of the major allergen phl p 1 from timothy grass Variants of the major allergen phl p 1 from timothy grass

C - Chemistry, Metallurgy

12

N

C12N 15/29 (2006.01) A61K 39/35 (2006.01) A61K 39/36 (2006.01) A61P 37/08 (2006.01) C07K 14/415 (2006.01)

Patent

CA 2495825

The invention relates to pharmaceutically significant variants of the major allergen Phl p 1 from timothy grass, and is characterised in that the previously impossible production of monomer molecules which are stable and soluble in physiological media can be carried out by means of prokaryotic expression systems, and said molecules can be subsequently purified.

L'invention concerne des variants d'intérêt pharmaceutique de l'allergène majeur Phl p 1 provenant de fléole des prés, caractérisés en ce que la fabrication de monomères, qui sont des molécules solubles et stables dans des milieux physiologiques, ayant été impossible jusque là, est rendue possible à l'aide de systèmes d'expression procaryotiques, tout comme le lavage consécutif desdits monomères.

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