Substituted aryl- and heteroaryl-phenyloxazolidinones

Details Substituted aryl- and heteroaryl-phenyloxazolidinones Substituted aryl- and heteroaryl-phenyloxazolidinones

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) C07D 263/20 (2006.01) C07D 417/10 (2006.01) C07D 471/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2119556

The present invention discloses novel substituted aryl- and heteroarylphenyloxazolidinones which are useful as anti-bacterial agents. Compounds according to the invention have a structure as shown in Formula XII. (see formula I) More specifically, the substituted aryl- and heteroarylphenyloxazolidinones of the invention are characterized by oxazolidinones having an aryl or heteroaryl group at the p- position of the 3- phenyl ring and additional substitutions at the m-position(s) of the 3-phenyl ring. A compound representative of this new class of oxazolidinones is (~)-5-(acetamidomethyl)- 3-[4-(3-pyridyl)- 3,5-difluorophenyl]-2-oxazolidinone.

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