Immunotherapy of autoimmune disorders using antibodies which...

Details Immunotherapy of autoimmune disorders using antibodies which... Immunotherapy of autoimmune disorders using antibodies which...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 37/06 (2006.01) C07K 14/55 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) A61K 38/12 (2006.01)

Patent

CA 2375912

Antibodies that bind with a B-cell antigen provide an effective means to treat autoimmune disorders. Antibodies and fragments, which may be conjugated or naked, are used alone or in multimodal therapies. The antibodies may be bispecific antibodies which may be produced recombinantly as fusion proteins, or as hybrid, polyspecific antibodies.

L'invention concerne des anticorps se liant à un antigène de cellules B et offrant un moyen efficace de traiter des troubles auto-immuns. Des anticorps et des fragments, qui peuvent être conjugués ou nus, sont utilisés isolément ou dans des thérapies multimodales. Les anticorps peuvent être des anticorps bispécifiques pouvant être produits par recombinaison en tant que protéines hybrides ou en tant qu'anticorps hybrides polyspécifiques.

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