C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/551 (2006.01)
Patent
CA 2718194
This invention relates to novel N-oxides of a 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivative and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
La présente invention concerne de nouveaux N-oxydes dun dérivé de 1,4-diaza-bicyclo[3.2.2]nonyloxadiazolyle et leur utilisation dans la fabrication de compositions pharmaceutiques. Il a été observé que les composés de linvention sont des ligands cholinergiques au niveau des récepteurs dacétylcholine nicotiniques. En raison de leur profil pharmacologique, les composés de linvention peuvent être utiles pour le traitement de maladies ou troubles aussi divers que ceux associés au système cholinergique du système nerveux central (SNC) ou du système nerveux périphérique (SNP), les maladies ou troubles associés à la contraction des muscles lisses, les maladies ou troubles endocriniens, les maladies ou troubles associés à la neurodégénérescence, les maladies ou troubles associés à linflammation, la douleur, et les symptômes de sevrage causés par larrêt de labus de substances chimiques.
Christoffersen Eva Dam
Nielsen Elsebet Østergaard
Peters Dan
Timmermann Daniel B.
Mccarthy Tetrault Llp
Neurosearch A/s
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