Substituted indole compounds as anti-inflammatory and...

Details Substituted indole compounds as anti-inflammatory and... Substituted indole compounds as anti-inflammatory and...

C - Chemistry, Metallurgy

07

D

C07D 209/40 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2281426

This invention provides a compound of the following formula: Image (I) or the pharmaceutically acceptable salts thereof wherein R1 is H or C1-4 alkyl; R2 is C(=L')R3 or SO2R4; Y is a direct bond or C1-4 alkylene; L and L' are independently oxygen or sulfur; Q is selected from the following: C1-6 alkyl, halo- substituted C1-4 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted phenyl or naphthyl, optionally substituted 5 or 6-membered monocyclic aromatic group; R3 is -OR6, -NR7R8, N(OR1)R7 or a group of formula: Image Z is a direct bond, O, S or NR5; R4 is C1-6 alkyl, halo-substituted C1-4 alkyl, optionally substituted phenyl or naphthyl; R5 is C1-4 alkyl or halo-substituted C1-4 alkyl; R6 is C1-4 alkyl, C3-7 cycloalkyl, C1-4 alkyl-C3-7 cycloalkyl, halo-substituted C1-4 alkyl, optionally substituted C1-4 alkyl-phenyl or phenyl; R7 and R8 are each selected from the following: H, optionally substituted C1-6 alkyl, optionally substituted C3- 7 cycloalkyl, optionally substituted C1-4 alkyl-C3-7 cycloalkyl, and optionally substituted C1-4 alkyl- phenyl or phenyl; X is each selected from halo, C1-4 alkyl, halo-substitutued C1-4 alkyl, OH, C1-4 alkoxy, halo-substitutued C1-4 alkoxy, C1-4 alkylthio, NO2, NH2, di- (C1-4 alkyl)amino and CN; n is 0, 1, 2 or 3; and r is 1, 2 or 3. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

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