C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/289
C07D 217/00 (2006.01) C07D 217/02 (2006.01) C07D 217/16 (2006.01) C07D 217/24 (2006.01) C07D 217/26 (2006.01)
Patent
CA 2033374
TITLE OF THE INVENTION Novel Isoquinoline Derivatives and Salts Thereof ABSTRACT The invention provides novel compounds and salts thereof, have the structure Image wherein R1 is a guianidinobenzoyloxy group and R2 is a hydrogen atom, a hydroxy, cyano, -COR3 (wherein R3 is an amino or lower alkyl group) or -COOR4 group [wherein R4 is a hydrogen atom, lower alkyl, phenyl, benzyl or -CH2CONR5R6 group (wherein R5 and R6 are the same or different and selected from a hydrogen atom and lower alkyl groups)], and wherein R1 is a hydroxy group and wherein R2 is a -COR3 (wherein R3 is an amino or lower alkyl group) or -COOR4 group [wherein R4 is a (C1, C3 or C4) alkyl, phenyl, benzyl or -CH2CONR5R6 group (wherein R5 and R6 are the same or different and selected from a hydrogen atom and lower alkyl groups)]. The compounds, wherein R1 is a guanidinobenzoyloxy group, are useful protease inhibitors as anti-trypsin agents.
Abe Noriko
Ishiguro Susumu
Koyama Tadayoshi
Kwaguchi Noboru
Nakamura Hiroshi
Dennison Associates
Snow Brand Milk Products Co. Ltd.
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