Receptor induced by lymphocyte activation in imflammatory...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2108401

ABSTRACT A receptor (ILA) isolated and substantially purified from lymphoid cells activated with proinflammatory agents is disclosed along with its nucleotide and amino acid sequences. Also disclosed are diagnostic and therapeutic methods of utilizing the ILA nucleotide and polypeptide sequences. ILA is also induced in primary chondrocytes by 11-1.beta. and cytokines that cause cartilage degradation.

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