A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/50 (2006.01) A61K 9/00 (2006.01) A61K 47/34 (2006.01)
Patent
CA 2649902
The present invention provides spherical microcapsules comprising at least one surface coating and a core, wherein the at least one surface coating comprises cross-linked polymers, and wherein the core comprises cross-linked polymers and cells capable of expressing and secreting a GLP-1 peptide, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof. The present application is furthermore directed to methods for production of these spherical microcapsules and to the use of these microcapules e.g. in the treatment of type 2 diabetes, weight disorders and diseases or conditions associated thereto, neurodegenerative disorders and diseases or conditions associated thereto, or for the treatment of disorders and diseases or conditions associated to apoptosis.
L'invention concerne des microcapsules sphériques comprenant au moins un enrobage de surface et un noyau, cet enrobage de surface comprenant des polymères réticulés et le noyau comprenant des polymères réticulés et des cellules pouvant exprimer et sécréter un peptide GLP-1, un fragment ou un variant de celui-ci ou un peptide de fusion comprenant GLP-1 ou un fragment ou un variant de celui-ci. L'invention concerne également des procédés de production de telles microcapsules sphériques et l'utilisation de ces microcapules pour traiter, par exemple, des diabètes du type 2, des troubles pondéraux, et des maladies ou des états pathologiques associés; des troubles neurodegénératifs et des maladies ou des états pathologiques associés; ou pour traiter des troubles et maladies ou des états pathologiques associés une apoptose.
Geigle Peter
Thoenes Eric
Thuermer Frank
Wallrapp Christine
Biocompatibles Uk Ltd.
Kirby Eades Gale Baker
LandOfFree
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