New lysosphingolipid derivitives

Details New lysosphingolipid derivitives New lysosphingolipid derivitives

C - Chemistry, Metallurgy

07

C

167/179, 260/228

C07C 233/17 (2006.01) A61K 31/16 (2006.01) C07C 215/24 (2006.01) C07C 233/18 (2006.01) C07C 233/20 (2006.01) C07C 235/08 (2006.01) C07C 237/04 (2006.01) C07C 237/22 (2006.01) C07C 255/19 (2006.01) C07C 323/58 (2006.01) C07F 9/10 (2006.01) C07H 15/04 (2006.01) C07H 15/10 (2006.01)

Patent

CA 2004190

Abstract of the Disclosure Novel derivatives of lysophingolipids free from sialic acids which are N-acyllysosphingolipids having one of the two formulae: Image (I) (II) in which -A- stands for the group -CH=CH- or -CH2-CH2-, n1 is a whole number of between 6 and 18, n2 a whole number of between 11 and 15, X is a hydrogen atom or the residue of a monosaccharide or a disaccharide or phosphorylcholine and R represents an alkyl radical derived from a saturated or unsaturated aliphatic carboxylic acid having from 2 to 24 carbon atoms substituted by one or more polar groups. The lysosphingolipid derivatives of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.

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