A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/02 (2006.01)
Patent
CA 2592542
The present invention is directed to drug dosage forms that can be used to treat diseases characterized by abnormal gastric acid secretion. The dosage forms have a core containing a proton pump inhibitor surrounded by an enteric coating or multiple particles containing proton pump inhibitor, each particle being surrounded by an enteric coating. The enteric coating delays the release of drug until the surrounding pH has risen. The tablets also include an outer coating that contains either a proton pump inhibitor or an H2 blocker. The outer coating is designed to rapidly dissolve in a patient's stomach.
L'invention concerne des formes dosifiées qui peuvent servir à traiter certaines maladies caractérisées par une sécrétion anormale d'acide gastrique. Ces formes dosifiées possèdent un noyau qui renferme un inhibiteur de la pompe à protons entouré d'un enrobage gastrorésistant ou de multiples particules contenant un inhibiteur de la pompe à protons, chaque particule étant entourée de l'enrobage gastrorésistant. L'enrobage gastrorésistant retarde la libération du médicament jusqu'à ce que le pH environnant augmente. De plus, ces comprimés possèdent un enrobage extérieur qui renferme soit un inhibiteur de la pompe à protons soit un antagoniste des récepteurs H2. L'enrobage extérieur est conçu pour se dissoudre rapidement dans l'estomac du patient.
Pozen Inc.
Smart & Biggar
LandOfFree
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