Micro-rnas of the mir-15 family modulate cardiomyocyte...

Details Micro-rnas of the mir-15 family modulate cardiomyocyte... Micro-rnas of the mir-15 family modulate cardiomyocyte...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 15/113 (2010.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2705325

A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of cardiomyocytes. Strategies to block expression of the miR-15 family in the heart as a treatment for diverse cardiac disease are provided.

L'invention concerne une famille de micro-ARN, appelée famille miR-15, qui comprend miR-195. Selon l'invention, les éléments de cette famille sont régulés à la hausse pendant un remodelage cardiaque pathologique et répriment l'expression des ARNm exigée pour la prolifération et la survie cellulaire, avec une perte conséquente de cardiomyocytes. Il est proposé des stratégies pour bloquer l'expression de la famille miR-15 dans le cur sous la forme d'un traitement de diverses maladies cardiaques.

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