C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2676640
The present invention relates to a novel polypeptide having ant i- tumor activity through inducing apoptosis of endothelial cell and use thereof. More particularly, the present invention relates to a method for inducing apoptosis of endothelial cell, and for preventing or treating cancer, comprising administering to a subject in need thereof an effective amount of (a) an isolated polypeptide having the amino acid sequence of SEQ ID NO: 9 or the amino acid sequence having at least 90% sequence homology to the amino acid sequence of SEQ ID NO: 9; or (b) an isolated polynucleotide encoding the polypeptide of (a).
La présente invention concerne un nouveau polypeptide ayant une activité antitumorale par l'induction de l'apoptose de cellule endothéliale, et son utilisation. Cette invention concerne en particulier un procédé d'induction de l'apoptose de cellule endothéliale, et de prévention et de traitement du cancer, ce procédé consistant à administrer, à un sujet nécessitant ce traitement, une quantité efficace (a) d'un polypeptide isolé ayant la séquence d'acides aminés SEQ ID NO: 9 ou la séquence d'acides aminés ayant au moins 90 % d'un homologue de séquence par rapport à la séquence d'acides aminés SEQ ID NO: 9; (b) d'un polynucléotide isolé codant le polypeptide de (a).
Han Jung Min
Kim Sunghoon
Lee Yoen Sook
Park Sang Gyu
Borden Ladner Gervais Llp
Imagene Co. Ltd.
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