Therapeutic uses for mesenchymal stromal cells

A - Human Necessities – 61 – K

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A61K 35/12 (2006.01) A61P 25/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2406196

Human mesenchymal stromal cells can be induced to differentiate into oligodendrocytes and neurons, respectively. For these cell types, therefore, MSCs can be a therapeutic source, either in vitro or in vivo, in the context of treating pathologies of the central nervous system which are characterized by neuron loss, such as Parkinson's disease, Alzheimer's disease and stroke, as well as head trauma, or by dysfunction in ganglioside storage or demyelinization, such as Tay-Sachs disease, G1 gangliosidosis, metachromatic leukodystrophy, and multiple sclerosis.

L'invention concerne des cellules stromales mésenchymateuses humaines pouvant être induites pour assurer une différenciation des oligodendrocytes et des neurones, respectivement. Par conséquent, pour ces types de cellules, les cellules stromales mésenchymateuses peuvent constituer une source thérapeutique, soit <i>in vitro</i> soit <i>in vivo</i>, dans le contexte du traitement de pathologies du système nerveux central caractérisées par une perte de neurones, par ex. la maladie de Parkinson, la maladie d'Alzheimer et l'apoplexie, ainsi que le traumatise crânien, ou par des dysfonctionnements de l'accumulation de gangliosides ou la démyélinisation, par ex. la maladie de Tay-Sachs, la gangliosidose G1, la leucodystrophie métachromatique, et la sclérose en plaques.

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