C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/08 (2006.01) B01J 31/22 (2006.01) C07C 6/06 (2006.01) C07F 15/00 (2006.01) C07K 1/08 (2006.01) C07K 1/113 (2006.01) C07K 5/06 (2006.01)
Patent
CA 2521835
The invention relates to an improved process for the preparation of a macrocyclic compound of formula I wherein R1, R2, R3, A and D have the meaning given in the claims; by a ring closure metathesis of the corresponding diene of formula III wherein R1, R2, R3, A and D' have the meaning given in the claims; in the presence of a benzylidene ruthenium catalyst, wherein the phenyl group is substituted by a nitro group.
La présente invention concerne un procédé amélioré pour préparer un composé macrocyclique de formule (I), dans laquelle R¿1?, R?2¿, R?3¿, A et D ont la signification donnée dans les revendications, par métathèse à cyclisation du diène correspondant de formule (III), dans laquelle R¿1?, R?2¿, R?3¿, A et D' ont la signification donnée dans les revendications, en présence d'un catalyseur de ruthénium benzylidène, le groupe phényle étant substitué par un groupe nitro.
Dersch Wolfgang
Samstag Wendelin
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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