Copolymer-based films, applications thereof in transdermal...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01) C08J 5/18 (2006.01) C08L 23/08 (2006.01) C08L 31/04 (2006.01) C08L 57/00 (2006.01)

Patent

CA 2130332

Copolymer-based films, applications thereof in transdermal systems and processes for their preparation. Said films consist of a vinyl ethylene/acetate type hydrophobic polymer containing at least one active principle and including 15 to 50 % hydrophilic inclusions formed from at least one hydrophilic monomer selected from the group comprising acrylamide, methylol acrylamide, diacetone acrylamide, maleic acid, acrylic acid, fumaric acid, itaconic acid, propylene glycol acrylate, ethylene glycol methacrylate, methacrylamide, methacrylic acid, propylene glycol methacrylate, hydroxyethyl methacrylate, dimethylaminoethyl methacrylate, N-vinylpyrrolidone, vinylacetic acid, vinylsulfonic acids.

2130332 9414425 Films à base de copolymères, leurs applications dans des systèmes transdermiques et leurs procédés de préparation. Lesdits films sont constitués par un polymère hydrophobe de type éthylène/acétate de vinyle (EVA) contenant au moins un principe actif et comportant 15 à 50 % d'inclusions hydrophiles formées à partir d'au moins un monomère hydrophile choisi dans le groupe qui comprend l'acrylamide, le méthylol acrylamide, le diacétone acrylamide, l'acide maléique, l'acide acrylique, l'acide fumarique, l'acide itaconique, l'acrylate de propylène glycol, le méthacrylate d'éthylène glycol, le méthacrylamide, l'acide méthacrylique, le méthacrylate de propylène glycol, le méthacrylate d'hydroxyéthyle, le méthacrylate de diméthylaminoéthyle, la N-vinylpyrrolidone, l'acide vinylacétique, les acides vinylsulfoniques.

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