A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/17 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2252492
Described is the use of acyl urea compounds for the treatment or prophylaxis of Coccidioides immitis infections in warm-blooded animals, preferably the treatment or prophylaxis of coccidioidomycosis in dogs or cats by the use of a therapeutic effective amount of an acyl urea represented by formula (I), wherein R1 is unsubstituted or substituted phenyl, naphthyl, pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl, R2 is hydrogen or C1-C6alkyl, R3 is (A) or (B), R4 to R8 are each independently hydrogen, halogen, C1-C6-alkyl, C1- C6haloalkyl, C1-C6alkoxy, C1-C6-haloalkoxy or C1-C6alkylthio, R9 is hydrogen or C1-C6alkyl, and X+ is a pharmaceutically or agronomically acceptable inorganic or organic cation; and pharmaceutically or agronomically acceptable salts thereof. Described are as well said compounds for the treatment or prophylaxis of C. immitis infections and their use for the preparation of pharmaceutical compositions against Coccidioides immitis infections.
Utilisation de composés d'acyl urée pour le traitement ou la prophylaxie des infections dues à Coccidioides immitis chez des animaux à sang chaud, de préférence pour le traitement ou la prophylaxie de la coccidiomycose chez les chiens et les chats grâce à l'utilisation d'une quantité thérapeutiquement efficace d'une acyl urée de formule générale (I) dans laquelle R¿1? est phényle, naphtyle, pyridyle, pyridazinyle, pyrimidinyle ou pyrazinyle substitués ou non substitués, R¿2? est hydrogène ou alkyle C¿1?-C¿6?, R¿3? est de formule (A) ou (B), R¿4? à R¿8? sont chacun indépendamment hydrogène, halogène, alkyle C¿1?-C¿6?, haloalkyle C¿1?-C¿6?, alcoxy C¿1?-C¿6?, haloalcoxy C¿1?-C¿6? ou alkylthio C¿1?-C¿6?, R¿9? est hydrogène ou alkyle C¿1?-C¿6?, et X?+¿ est un cation organique ou inorganique acceptable sur le plan pharmaceutique ou agronomique, et sels desdits composés acceptables sur le plan pharmaceutique ou agronomique. La présente invention concerne également l'utilisation desdits composés pour le traitement ou la prophylaxie d'infections dues à C. immitis et leur utilisation pour la préparation de compositions pharmaceutiques contre les infections dues à Coccidioides immitis.
Bartsch Robert Carl
Greene Russell Thomas
Fetherstonhaugh & Co.
Novartis Ag
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