Targeted carrier fusions for delivery of chemotherapeutic...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) A61K 38/16 (2006.01) C07K 7/06 (2006.01) C07K 7/64 (2006.01) C07K 14/36 (2006.01) C12N 1/21 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2534708

The present invention provides for fusion proteins that act as targeted drug carriers. The proteins are derived from molecules that possess natural drug- binding capabilities that are further engineered to target specific cell types, and optionally to have altered/improved drug binding characteristics. These fusion proteins are useful in, for example, delivery of chemotherapeutic compounds to cancer cells.

L'invention concerne des protéines hybrides qui agissent en tant que vecteurs de médicaments cibles. Les protéines sont dérivées de molécules qui possèdent des possibilités naturelles de liaison du médicament, lesquelles sont de plus transformées en types de cellules spécifiques cibles, et elles présentent éventuellement des caractéristiques de liaison de médicaments transformées/améliorées. Lesdites protéines hybrides sont utilisées dans l'administration, par exemple, de composés thérapeutiques à des cellules cancéreuses.

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