Preparation of hollow microcapsules

B - Operations – Transporting – 01 – J

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B01J 13/04 (2006.01) A61K 9/50 (2006.01) A61K 49/00 (2006.01) A61K 49/22 (2006.01) A61L 2/08 (2006.01)

Patent

CA 2177492

A process for forming microcapsules comprising (i) providing a solution of protein in an aqueous solvent and (ii) spraying the said solution into a gas such that the aqueous solvent evaporates, thereby forming hollow microcapsules, characterised in that the aqueous solution contains a liquid of greater volatility than water. The protein is preferably ethanol. The microcapsules may be used as ultrasound echogenic contrast agents.

Procédé de formation de microcapsules comprenant les étapes consistant à (i) produire une solution d'une protéine dans un solvant aqueux, et (ii) à vaporiser cette solution dans un gaz de telle manière que le solvant aqueux s'évapore et qu'il y ait ainsi formation de microcapsules creuses, ce procédé étant caractérisé en ce que la solution aqueuse contient un liquide d'une volatilité supérieure à celle de l'eau. De préférence, la protéine est de l'albumine et le liquide volatil est de l'éthanol. On peut utiliser ces microcapsules en tant qu'agents de contraste échogènes dans l'imagerie à ultrasons.

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