Method for treatment of papulo-pustules and comedones of the...

A - Human Necessities – 61 – K

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A61K 33/40 (2006.01) A61K 7/48 (1995.01) A61K 31/61 (1995.01)

Patent

CA 2179188

Papulo-pustules in the skin of patients suffering from various forms of acne, folliculitis and rosacea may be rapidly resolved by a spot therapy which involves topically applying to the exterior surface of the papulo-pustule (pimple) an aqueous solution containing hydrogen peroxide and preferably also at least one fruit acid and/or salicylic acid. A preferred fruit acid is glycolic acid. Both open and closed comedones are also effectively treated by spot therapy with the aqueous solution containing hydrogen peroxide, fruit acid and salicylic acid. The solution preferably contains 3 to 6 weight percent hydrogen peroxide, 2 to 4 weight percent glycolic acid and 2 to 4 weight percent salicylic acid, and is preferably applied 2 to 3 times daily. Treatments continue for 1 to 3 days when directed to papulo-pustules and 7 to 20 days when directed to comedones. The therapy also substantially reduces or avoids hyperpigmentation and scarring after resorption of the papulo-pustules. Application of the hydrogen peroxide solution to the earliest spot (lesion) prevents developement of larger papulo-pustules and reduces the possibility of scarring and hyperpigmentation.

Traitement anti-acné permettant d'éliminer rapidement les papulopustules de la peau des malades atteints de diverses formes d'acné, de folliculite et d'acné rosacée. Le traitement consiste en une application topique sur la face externe de la papulopustule (bouton) d'une solution aqueuse renfermant de l'eau oxygénée et, de préférence, au moins un acidulant et/ou de l'acide salicylique. L'acidulant préféré est l'acide glycolique. On peut également traiter efficacement les comédons ouverts et fermés par traitement anti-acné à l'aide de la solution aqueuse renfermant de l'eau oxygénée, un acidulant et de l'acide salicylique. La solution contient,de préférence, 3 à 6 % en poids d'eau oxygénée, 2 à 4 % en poids d'acide glycolique, et 2 à 4 % en poids d'acide salicylique, et on l'applique 2 ou 3 fois par jour. Le traitement dure de 1 à 3 jours lorsqu'il est dirigé contre les papulopustules, et de 7 à 20 jours lorsqu'il est dirigé contre les comédons. Le traitement permet également de réduire sensiblement ou d'éviter l'hyperpigmentation et la cicatrisation après la résorption des papulopustules. L'application de la solution d'eau oxygénée dès l'apparition du premier bouton (lésion) empêche l'apparition de papulopustules plus grandes et réduit le risque d'hyperpigmentation et de cicatrisation.

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