C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 257/06 (2006.01) A61K 31/137 (2006.01) A61K 31/41 (2006.01) A61K 31/421 (2006.01) A61P 9/10 (2006.01) C07C 215/74 (2006.01) C07D 249/04 (2006.01) C07D 261/14 (2006.01)
Patent
CA 2624032
Compounds of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), A1 and A2 are each an aromatic ring, a 5-6- membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring, and Z is an aromatic or heterocyclic ring.
L'invention concerne des composés de formule (I), y compris des sels pharmaceutiquement acceptables de ces composés, qui constituent des inhibiteurs de la protéine de transfert des esters de cholestérol (CETP) et peuvent servir à augmenter le taux de cholestérol HDL, à réduire le taux de cholestérol LDL, et à traiter ou prévenir l'athérosclérose. Dans ladite formule (I), A1 et A2 représentent respectivement un noyau aromatique, un noyau hétérocyclique à 5-6 chaînons, un noyau aromatique condensé avec un noyau hétérocyclique, un noyau phényle condensé avec un noyau hétérocyclique, ou un noyau cycloalkyle, et Z désigne un noyau aromatique ou hétérocyclique.
Ali Amjad
Sinclair Peter J.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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