Substituted pyrazine inhibitors of akt

Details Substituted pyrazine inhibitors of akt Substituted pyrazine inhibitors of akt

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) C07D 241/10 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2481229

The present invention is directed to compounds comprising a 2,3- diphenylpyrazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. An example of a suitable compound includes a compound of Formula A: (see formula A)

La présente invention concerne des composés comprenant un groupe fonctionnel 2,3-diphénylpyrazine inhibant l'activité de Akt, une protéine kinase serine/thréonine. L'invention concerne également des compositions chimiothérapeutiques contenant ces composés. L'invention concerne également des méthodes permettant de traiter le cancer par administration des composés susmentionnés.

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