C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/86 (2006.01) A61K 31/15 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07C 309/46 (2006.01) C07C 309/66 (2006.01) C07C 311/48 (2006.01) C07C 323/48 (2006.01) C07D 295/12 (2006.01)
Patent
CA 2571990
The invention relates to the novel ortho-substituted (3-hydroxyphenyl)-acetic acid benzylidene hydrazides of formula (I), wherein R1 to R9 are defined as in claim 1. Said novel compounds are SGK inhibitors and can be used in the treatment of SGK-relates diseases and disorders such as diabetes, obesity, metabolic syndrome (dyslipidemia), systemic and pulmonary hypertension, cardiovascular diseases and renal diseases, and generally for any kind of fibroses and inflammatory processes.
L'invention concerne de nouveaux hydrazides de benzylidène d'acide (3-hydroxyphényl)acétique ortho-substitués de formule (I), dans laquelle R1- R9 ont les significations indiquées dans la revendication 1. Ces composés sont des inhibiteurs de SGK et peuvent être utilisés dans le traitement de maladies et troubles causés par SGK, tels que le diabète, l'obésité, le syndrome métabolique (dyslipidémie), l'hypertonie pulmonaire et systémique, les maladies cardiovasculaires et les maladies rénales, de manière générale, pour tout type de fibroses et processus inflammatoires.
Beier Norbert
Dorsch Dieter
Gericke Rolf
Lang Florian
Mederski Werner
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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