Novel human lim proteins

Details Novel human lim proteins Novel human lim proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2272825

The present invention provides three human LIM proteins (designated individually as HLIM-1, HLIM-2, and HLIM-3, and collectively as HLIM) and polynucleotides which identify and encode HLIM. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HLIM and a method for producing HLIM. The invention also provides for use of HLIM and agonists, antibodies, or antagonists specifically binding HLIM, in the prevention and treatment of diseases associated with expression of HLIM. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HLIM for the treatment of diseases associated with the expression of HLIM. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HLIM.

Cette invention concerne trois protéines humaines LIM (appelées chacune HLIM1, HLIM2 et HLIM3, et HLIM de manière collective), ainsi que des polynucléotides permettant d'identifier et de coder ces HLIM. Cette invention concerne également des vecteurs d'expression ainsi que des cellules hôtes qui comprennent les séquences d'acide nucléique codant l'HLIM, lesquels ont été obtenus par génie génétique. Cette invention concerne aussi un procédé de production d'HLIM, ainsi que l'utilisation d'HLIM et celle d'agonistes, d'anticorps et d'antagonistes se liant spécifiquement à l'HLIM, dans la prévention et le traitement de maladies associées à l'expression d'HLIM. Cette invention concerne en outre l'utilisation de molécules antisens sur des polynucléotides codant l'HLIM en vue du traitement de maladies associées à l'expression d'HLIM. Cette invention concerne enfin des analyses diagnostiques qui font appel au polynucléotide, ou à des fragments ou au complément de celui-ci, ainsi qu'à des anticorps se liant spécifiquement à l'HLIM.

Affiliated with

Also associated with

Rating

Novel human lim proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel human lim proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel human lim proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1549360